Drug interactions
Sertraline + Zolmitriptan
Severity: Moderate
Sertraline and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SSRI with a triptan can in rare cases lead to serotonin syndrome, with agitation, tremor, sweating, hyperthermia, clonus and autonomic instability. Most patients take the combination without problems, but the risk is real enough to warrant awareness.
What this interaction means in plain words
Sertraline and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sertraline belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from SSRI-mediated reuptake inhibition and triptan 5-HT1B/1D agonism.
What to do
Counsel the patient to report agitation, tremor, fever, diarrhea or muscle twitching promptly. Stop one or both drugs if serotonin toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Sertraline with Zolmitriptan?
MediHelp rates the interaction as moderate. Sertraline and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SSRI with a triptan can in rare cases lead to serotonin syndrome, with agitation, tremor, sweating, hyperthermia, clonus and autonomic instability. Most patients take the combination without problems, but the risk is real enough to warrant awareness.
How serious is the interaction between Sertraline and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, fever, diarrhea or muscle twitching promptly. Stop one or both drugs if serotonin toxicity is suspected.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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