Drug interactions
Sevoflurane + Timolol
Severity: Moderate
Sevoflurane and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane causes vasodilation and myocardial depression, and beta-blockade limits the compensatory heart rate response, so hypotension and bradycardia may be more pronounced during anesthesia.
What this interaction means in plain words
Sevoflurane and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Why it happens
Additive cardiovascular depression from volatile anesthetic vasodilation and beta-blockade of compensatory sympathetic responses.
What to do
Monitor blood pressure and ECG continuously and titrate anesthetic depth carefully. Have vasopressors and anticholinergics available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Sevoflurane with Timolol?
MediHelp rates the interaction as moderate. Sevoflurane and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane causes vasodilation and myocardial depression, and beta-blockade limits the compensatory heart rate response, so hypotension and bradycardia may be more pronounced during anesthesia.
How serious is the interaction between Sevoflurane and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ECG continuously and titrate anesthetic depth carefully. Have vasopressors and anticholinergics available.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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