Drug interactions
Sevoflurane + Zuranolone
Severity: Moderate
Sevoflurane and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and psychomotor impairment, and sevoflurane produces profound CNS depression. Together they can intensify sedation and delay recovery from anesthesia.
What this interaction means in plain words
Sevoflurane and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A receptor positive modulation by both agents.
What to do
Tell the anesthesia team about recent zuranolone use and titrate anesthetic doses to effect. Monitor sedation level and ventilation closely through recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Sevoflurane with Zuranolone?
MediHelp rates the interaction as moderate. Sevoflurane and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and psychomotor impairment, and sevoflurane produces profound CNS depression. Together they can intensify sedation and delay recovery from anesthesia.
How serious is the interaction between Sevoflurane and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about recent zuranolone use and titrate anesthetic doses to effect. Monitor sedation level and ventilation closely through recovery.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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