Drug interactions
Sildenafil + Tucatinib
Severity: Moderate
Sildenafil and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may increase sildenafil concentrations. This raises the likelihood of hypotension and other dose-related adverse effects.
What this interaction means in plain words
Sildenafil and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sildenafil belongs to Genitourinary; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, decreasing sildenafil clearance.
What to do
Use a reduced sildenafil dose, such as 25 mg for erectile dysfunction, and monitor blood pressure. Avoid for pulmonary hypertension if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Sildenafil with Tucatinib?
MediHelp rates the interaction as moderate. Sildenafil and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and may increase sildenafil concentrations. This raises the likelihood of hypotension and other dose-related adverse effects.
How serious is the interaction between Sildenafil and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced sildenafil dose, such as 25 mg for erectile dysfunction, and monitor blood pressure. Avoid for pulmonary hypertension if possible.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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