Drug interactions
Sirolimus + Vinblastine
Severity: Minor
Sirolimus and Vinblastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus is a P-glycoprotein substrate and may modestly increase vinblastine exposure by competing for efflux. Both drugs can cause myelosuppression, and the clinical effect is usually small.
What this interaction means in plain words
Sirolimus and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sirolimus belongs to Miscellaneous; Vinblastine belongs to Oncology.
Why it happens
Sirolimus may competitively inhibit P-glycoprotein efflux of vinblastine.
What to do
Monitor blood counts and adjust the vinblastine dose only if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinblastine
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Sirolimus with Vinblastine?
MediHelp rates the interaction as minor. Sirolimus and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sirolimus is a P-glycoprotein substrate and may modestly increase vinblastine exposure by competing for efflux. Both drugs can cause myelosuppression, and the clinical effect is usually small.
How serious is the interaction between Sirolimus and Vinblastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and adjust the vinblastine dose only if toxicity occurs.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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