Drug interactions
Sirolimus + Vonoprazan
Severity: Moderate
Sirolimus and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan is a weak CYP3A inhibitor and may modestly increase sirolimus concentrations. The effect is likely small but relevant given sirolimus's narrow therapeutic range.
What this interaction means in plain words
Sirolimus and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sirolimus belongs to Miscellaneous; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Weak CYP3A4 inhibition by vonoprazan reduces sirolimus metabolism.
What to do
Check sirolimus trough levels after starting or stopping vonoprazan. Adjust the sirolimus dose if levels move out of range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Sirolimus with Vonoprazan?
MediHelp rates the interaction as moderate. Sirolimus and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan is a weak CYP3A inhibitor and may modestly increase sirolimus concentrations. The effect is likely small but relevant given sirolimus's narrow therapeutic range.
How serious is the interaction between Sirolimus and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sirolimus trough levels after starting or stopping vonoprazan. Adjust the sirolimus dose if levels move out of range.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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