Drug interactions
Sitagliptin + Testosterone
Severity: Minor
Sitagliptin and Testosterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Testosterone replacement may improve insulin sensitivity and lower glucose, which might add slightly to the effect of sitagliptin. The effect is generally small.
What this interaction means in plain words
Sitagliptin and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sitagliptin belongs to Endocrine; Testosterone belongs to Endocrine.
Why it happens
Possible additive improvement in insulin sensitivity; the mechanism is not firmly established.
What to do
Monitor blood glucose after starting or changing testosterone. Adjust antidiabetic therapy only if readings change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Other interactions of Testosterone
- Testosterone + Warfarin Major
- Androstenedione + Testosterone Moderate
- Betamethasone + Testosterone Moderate
- Carbamazepine + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
Frequently asked questions
Can I take Sitagliptin with Testosterone?
MediHelp rates the interaction as minor. Sitagliptin and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Testosterone replacement may improve insulin sensitivity and lower glucose, which might add slightly to the effect of sitagliptin. The effect is generally small.
How serious is the interaction between Sitagliptin and Testosterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing testosterone. Adjust antidiabetic therapy only if readings change.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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