Drug interactions
Sitagliptin + Tipranavir
Severity: Moderate
Sitagliptin and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, a protease inhibitor given with ritonavir, may cause insulin resistance and hyperglycemia that can weaken sitagliptin's effect. Tipranavir also modulates P-glycoprotein, with uncertain effect on sitagliptin.
What this interaction means in plain words
Sitagliptin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sitagliptin belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Pharmacodynamic antagonism through protease inhibitor-induced insulin resistance.
What to do
Monitor glucose and HbA1c and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Sitagliptin with Tipranavir?
MediHelp rates the interaction as moderate. Sitagliptin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, a protease inhibitor given with ritonavir, may cause insulin resistance and hyperglycemia that can weaken sitagliptin's effect. Tipranavir also modulates P-glycoprotein, with uncertain effect on sitagliptin.
How serious is the interaction between Sitagliptin and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c and adjust antidiabetic therapy if control worsens.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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