Drug interactions
Sofosbuvir + Sotorasib
Severity: Minor
Sofosbuvir and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a weak P-gp inhibitor and CYP3A4 inducer, so sofosbuvir exposure could increase slightly. Clinical impact is probably small.
What this interaction means in plain words
Sofosbuvir and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sofosbuvir belongs to Anti Virals; Sotorasib belongs to Oncology.
Why it happens
Sotorasib may weakly inhibit intestinal P-gp, increasing sofosbuvir absorption.
What to do
No dose adjustment is needed; monitor for sofosbuvir adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Sofosbuvir with Sotorasib?
MediHelp rates the interaction as minor. Sofosbuvir and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib is a weak P-gp inhibitor and CYP3A4 inducer, so sofosbuvir exposure could increase slightly. Clinical impact is probably small.
How serious is the interaction between Sofosbuvir and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for sofosbuvir adverse effects.
What other medicines interact with Sofosbuvir?
MediHelp also lists interactions of Sofosbuvir with, for example, Amiodarone, Apalutamide, Carbamazepine. The full list is on the Sofosbuvir page.
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