Drug interactions
Sofosbuvir-velpatasvir + Temsirolimus
Severity: Minor
Sofosbuvir-velpatasvir and Temsirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits intestinal P-glycoprotein and could modestly raise exposure to P-gp substrates. Temsirolimus is a weak P-gp substrate, with most of its activity coming from its metabolite sirolimus, so a meaningful change in toxicity is not expected.
What this interaction means in plain words
Sofosbuvir-velpatasvir and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sofosbuvir-velpatasvir belongs to Anti Virals; Temsirolimus belongs to Oncology.
Why it happens
Velpatasvir inhibits P-glycoprotein efflux, potentially increasing absorption or reducing clearance of substrates.
What to do
No dose change is usually needed; monitor for temsirolimus adverse effects such as mucositis, cytopenias and hyperglycemia during the hepatitis C treatment course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Sofosbuvir-velpatasvir with Temsirolimus?
MediHelp rates the interaction as minor. Sofosbuvir-velpatasvir and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir inhibits intestinal P-glycoprotein and could modestly raise exposure to P-gp substrates. Temsirolimus is a weak P-gp substrate, with most of its activity coming from its metabolite sirolimus, so a meaningful change in toxicity is not expected.
How serious is the interaction between Sofosbuvir-velpatasvir and Temsirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for temsirolimus adverse effects such as mucositis, cytopenias and hyperglycemia during the hepatitis C treatment course.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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