Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Sparsentan
Severity: Moderate
Sofosbuvir-velpatasvir-voxilaprevir and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan induces CYP2B6 and may lower velpatasvir exposure, which is partly metabolised by CYP2B6, CYP2C8 and CYP3A4. Reduced velpatasvir levels could compromise antiviral efficacy and the chance of a sustained virologic response.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals; Sparsentan belongs to Genitourinary.
Why it happens
Sparsentan induction of CYP2B6 (and weakly other enzymes) may increase velpatasvir metabolism.
What to do
Monitor HCV RNA response during therapy and confirm a sustained virologic response. Consider whether sparsentan can be timed or replaced if virologic response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sofosbuvir-velpatasvir-voxilaprevir and Sparsentan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Sparsentan?
MediHelp rates the interaction as moderate. Sofosbuvir-velpatasvir-voxilaprevir and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan induces CYP2B6 and may lower velpatasvir exposure, which is partly metabolised by CYP2B6, CYP2C8 and CYP3A4. Reduced velpatasvir levels could compromise antiviral efficacy and the chance of a sustained virologic response.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HCV RNA response during therapy and confirm a sustained virologic response. Consider whether sparsentan can be timed or replaced if virologic response is inadequate.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
