Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Voclosporin
Severity: Minor
Sofosbuvir-velpatasvir-voxilaprevir and Voclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin inhibits OATP1B1 and may increase voxilaprevir plasma concentrations. Voxilaprevir is an OATP1B1 substrate, so exposure may rise somewhat, though the clinical impact is likely limited.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals; Voclosporin belongs to Miscellaneous.
Why it happens
Voclosporin inhibits hepatic OATP1B1 uptake of voxilaprevir, which can raise its plasma concentrations.
What to do
No empirical dose change is needed. Monitor for adverse effects of the antiviral combination such as headache and gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Voclosporin?
MediHelp rates the interaction as minor. Sofosbuvir-velpatasvir-voxilaprevir and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voclosporin inhibits OATP1B1 and may increase voxilaprevir plasma concentrations. Voxilaprevir is an OATP1B1 substrate, so exposure may rise somewhat, though the clinical impact is likely limited.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Voclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for adverse effects of the antiviral combination such as headache and gastrointestinal upset.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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