Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Voxelotor
Severity: Minor
Sofosbuvir-velpatasvir-voxilaprevir and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor modestly inhibits CYP3A4 and may raise velpatasvir exposure. Velpatasvir has a wide therapeutic margin, so the effect is usually minor.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor weakly inhibits CYP3A4, reducing velpatasvir metabolism.
What to do
No dose adjustment is generally needed. Monitor for increased HCV drug adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sofosbuvir-velpatasvir-voxilaprevir and Voxelotor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Voxelotor?
MediHelp rates the interaction as minor. Sofosbuvir-velpatasvir-voxilaprevir and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor modestly inhibits CYP3A4 and may raise velpatasvir exposure. Velpatasvir has a wide therapeutic margin, so the effect is usually minor.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for increased HCV drug adverse effects.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
