Drug interactions
Solifenacin + Tetrabenazine
Severity: Moderate
Solifenacin and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine can prolong the QT interval, and solifenacin may add to this. The risk is greater with other QT risk factors or CYP2D6 poor metabolizer status.
What this interaction means in plain words
Solifenacin and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and electrolytes if combined. Consider an alternative bladder agent in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Solifenacin with Tetrabenazine?
MediHelp rates the interaction as moderate. Solifenacin and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetrabenazine can prolong the QT interval, and solifenacin may add to this. The risk is greater with other QT risk factors or CYP2D6 poor metabolizer status.
How serious is the interaction between Solifenacin and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes if combined. Consider an alternative bladder agent in patients with other QT risk factors.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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