Drug interactions
Solifenacin + Thioridazine
Severity: Major
Solifenacin and Thioridazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine strongly prolongs the QT interval and can cause torsades de pointes, and solifenacin has a dose-related QT effect that may add to the risk. Thioridazine is also an anticholinergic, adding to antimuscarinic burden.
What this interaction means in plain words
Solifenacin and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Solifenacin belongs to Genitourinary; Thioridazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with possible additive anticholinergic effects.
What to do
Avoid the combination and choose a non-QT-prolonging bladder agent. If unavoidable, obtain an ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Solifenacin with Thioridazine?
MediHelp rates the interaction as major. Solifenacin and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thioridazine strongly prolongs the QT interval and can cause torsades de pointes, and solifenacin has a dose-related QT effect that may add to the risk. Thioridazine is also an anticholinergic, adding to antimuscarinic burden.
How serious is the interaction between Solifenacin and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging bladder agent. If unavoidable, obtain an ECG and correct potassium and magnesium.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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