Drug interactions
Solifenacin + Tiotropium
Severity: Moderate
Solifenacin and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block muscarinic receptors, so combining them raises the risk of anticholinergic adverse effects. These include dry mouth, constipation, urinary retention and blurred vision.
What this interaction means in plain words
Solifenacin and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Tiotropium belongs to Respiratory.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for urinary retention, constipation and visual symptoms. Reduce the dose or choose an alternative if anticholinergic effects become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Other interactions of Solifenacin
Frequently asked questions
Can I take Solifenacin with Tiotropium?
MediHelp rates the interaction as moderate. Solifenacin and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block muscarinic receptors, so combining them raises the risk of anticholinergic adverse effects. These include dry mouth, constipation, urinary retention and blurred vision.
How serious is the interaction between Solifenacin and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and visual symptoms. Reduce the dose or choose an alternative if anticholinergic effects become troublesome.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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