Drug interactions
Solifenacin + Umeclidinium-vilanterol
Severity: Moderate
Solifenacin and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solifenacin is a systemic antimuscarinic that adds to the anticholinergic effects of inhaled umeclidinium, including dry mouth, constipation, urinary retention and blurred vision. Solifenacin also has a small QT effect that may add to vilanterol cardiac effects.
What this interaction means in plain words
Solifenacin and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism, with minor additive QT effects.
What to do
Monitor for anticholinergic adverse effects, particularly in older adults, and review need for both agents if they emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Solifenacin
Frequently asked questions
Can I take Solifenacin with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Solifenacin and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solifenacin is a systemic antimuscarinic that adds to the anticholinergic effects of inhaled umeclidinium, including dry mouth, constipation, urinary retention and blurred vision. Solifenacin also has a small QT effect that may add to vilanterol cardiac effects.
How serious is the interaction between Solifenacin and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, particularly in older adults, and review need for both agents if they emerge.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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