Drug interactions
Solifenacin + Verapamil
Severity: Moderate
Solifenacin and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a moderate CYP3A4 inhibitor and can raise solifenacin plasma concentrations. Higher exposure may increase anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision, and may add to QT-related risk at high solifenacin exposure.
What this interaction means in plain words
Solifenacin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4-mediated metabolism of solifenacin, reducing its clearance.
What to do
Monitor for anticholinergic adverse effects and urinary retention when starting verapamil. Keep the solifenacin dose at the lowest effective level.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Solifenacin and Verapamil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Solifenacin
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Solifenacin with Verapamil?
MediHelp rates the interaction as moderate. Solifenacin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil is a moderate CYP3A4 inhibitor and can raise solifenacin plasma concentrations. Higher exposure may increase anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision, and may add to QT-related risk at high solifenacin exposure.
How serious is the interaction between Solifenacin and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and urinary retention when starting verapamil. Keep the solifenacin dose at the lowest effective level.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
