Drug interactions
Solifenacin + Voclosporin
Severity: Moderate
Solifenacin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can prolong the QT interval at supratherapeutic exposure, and solifenacin may add to this effect. Voclosporin is also a CYP3A4 substrate with weak inhibitory activity on some pathways.
What this interaction means in plain words
Solifenacin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Voclosporin belongs to Miscellaneous.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG in patients with additional QT risk factors and maintain normal electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Solifenacin with Voclosporin?
MediHelp rates the interaction as moderate. Solifenacin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin can prolong the QT interval at supratherapeutic exposure, and solifenacin may add to this effect. Voclosporin is also a CYP3A4 substrate with weak inhibitory activity on some pathways.
How serious is the interaction between Solifenacin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with additional QT risk factors and maintain normal electrolytes.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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