Drug interactions
Sonidegib + Verapamil
Severity: Major
Sonidegib and Verapamil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may increase sonidegib exposure, raising the risk of adverse effects such as musculoskeletal toxicity including rhabdomyolysis and CK elevation.
What this interaction means in plain words
Sonidegib and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sonidegib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Moderate CYP3A4 inhibition by verapamil decreases the metabolism of sonidegib.
What to do
Avoid the combination. If unavoidable, limit verapamil use to under 14 days and monitor serum CK and muscle symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Sonidegib with Verapamil?
MediHelp rates the interaction as major. Sonidegib and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Verapamil may increase sonidegib exposure, raising the risk of adverse effects such as musculoskeletal toxicity including rhabdomyolysis and CK elevation.
How serious is the interaction between Sonidegib and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If unavoidable, limit verapamil use to under 14 days and monitor serum CK and muscle symptoms.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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