Drug interactions
Sorafenib + Stiripentol
Severity: Moderate
Sorafenib and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP3A4, so sorafenib exposure could rise or fall unpredictably. This might lead to toxicity or reduced antitumor effect.
What this interaction means in plain words
Sorafenib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sorafenib belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol altering sorafenib metabolism.
What to do
Monitor for sorafenib toxicity and for loss of efficacy. Adjust the sorafenib dose according to tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Stiripentol
Frequently asked questions
Can I take Sorafenib with Stiripentol?
MediHelp rates the interaction as moderate. Sorafenib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both inhibitory and inducing effects on CYP3A4, so sorafenib exposure could rise or fall unpredictably. This might lead to toxicity or reduced antitumor effect.
How serious is the interaction between Sorafenib and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib toxicity and for loss of efficacy. Adjust the sorafenib dose according to tolerability.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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