Drug interactions
Sorafenib + Trimipramine
Severity: Major
Sorafenib and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib can prolong the QT interval, and trimipramine adds to this effect, raising the risk of ventricular arrhythmias, particularly with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Sorafenib and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sorafenib belongs to Oncology; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Obtain a baseline and periodic ECG and keep potassium and magnesium in range. Consider an alternative antidepressant in patients with other QT risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Sorafenib with Trimipramine?
MediHelp rates the interaction as major. Sorafenib and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sorafenib can prolong the QT interval, and trimipramine adds to this effect, raising the risk of ventricular arrhythmias, particularly with electrolyte disturbance or cardiac disease.
How serious is the interaction between Sorafenib and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline and periodic ECG and keep potassium and magnesium in range. Consider an alternative antidepressant in patients with other QT risk factors.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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