Drug interactions
Sorafenib + Valbenazine
Severity: Moderate
Sorafenib and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib can prolong the QT interval, and valbenazine's active metabolite may cause a modest QT effect at higher exposures. Combined use could add to arrhythmia risk, particularly in patients with other risk factors.
What this interaction means in plain words
Sorafenib and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sorafenib belongs to Oncology; Valbenazine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check a baseline ECG and electrolytes, correcting potassium and magnesium abnormalities. Monitor the ECG periodically, particularly in patients with congenital long QT, bradycardia or heart failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Sorafenib with Valbenazine?
MediHelp rates the interaction as moderate. Sorafenib and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib can prolong the QT interval, and valbenazine's active metabolite may cause a modest QT effect at higher exposures. Combined use could add to arrhythmia risk, particularly in patients with other risk factors.
How serious is the interaction between Sorafenib and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, correcting potassium and magnesium abnormalities. Monitor the ECG periodically, particularly in patients with congenital long QT, bradycardia or heart failure.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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