Drug interactions
Sotalol + Tadalafil
Severity: Minor
Sotalol and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil has mild vasodilating effects that may add to the blood pressure lowering of the beta-blocker sotalol. The clinical effect is usually small but hypotension can occur.
What this interaction means in plain words
Sotalol and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sotalol belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive blood pressure lowering from PDE5 inhibition and beta-blockade.
What to do
Monitor blood pressure when starting tadalafil. No dose change is normally required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Sotalol with Tadalafil?
MediHelp rates the interaction as minor. Sotalol and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tadalafil has mild vasodilating effects that may add to the blood pressure lowering of the beta-blocker sotalol. The clinical effect is usually small but hypotension can occur.
How serious is the interaction between Sotalol and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting tadalafil. No dose change is normally required.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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