Drug interactions
Sotalol + Terazosin
Severity: Moderate
Sotalol and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terazosin adds to the blood pressure lowering of sotalol, increasing the chance of orthostatic hypotension and dizziness. Hypotension and bradycardia in a patient taking sotalol also matter because of its proarrhythmic potential.
What this interaction means in plain words
Sotalol and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sotalol belongs to Cardiovascular; Terazosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic hypotension from alpha-1 blockade and beta-blockade.
What to do
Monitor blood pressure, heart rate and symptoms of dizziness when starting or changing terazosin, and titrate slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Sotalol with Terazosin?
MediHelp rates the interaction as moderate. Sotalol and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terazosin adds to the blood pressure lowering of sotalol, increasing the chance of orthostatic hypotension and dizziness. Hypotension and bradycardia in a patient taking sotalol also matter because of its proarrhythmic potential.
How serious is the interaction between Sotalol and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and symptoms of dizziness when starting or changing terazosin, and titrate slowly.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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