Drug interactions
Sotalol + Timolol
Severity: Major
Sotalol and Timolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is itself a non-selective beta-blocker, so adding timolol duplicates beta-blockade. This may cause marked bradycardia, hypotension and AV block, and sotalol's proarrhythmic risk makes bradycardia more hazardous.
What this interaction means in plain words
Sotalol and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sotalol belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic beta-adrenergic receptor antagonism.
What to do
Avoid the combination and use a single beta-blocker. If it cannot be avoided, monitor ECG, heart rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Sotalol with Timolol?
MediHelp rates the interaction as major. Sotalol and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol is itself a non-selective beta-blocker, so adding timolol duplicates beta-blockade. This may cause marked bradycardia, hypotension and AV block, and sotalol's proarrhythmic risk makes bradycardia more hazardous.
How serious is the interaction between Sotalol and Timolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a single beta-blocker. If it cannot be avoided, monitor ECG, heart rate and blood pressure.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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