Drug interactions
Sotalol + Triamterene
Severity: Moderate
Sotalol and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a nonselective beta-blocker that may modestly raise potassium, and triamterene retains potassium. Hyperkalemia can alter cardiac conduction, and sotalol's QT effects make electrolyte disturbances of particular concern.
What this interaction means in plain words
Sotalol and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sotalol belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Triamterene reduces renal potassium excretion and beta-2 blockade impairs cellular potassium uptake.
What to do
Monitor serum potassium and ECG as appropriate, and keep potassium within the normal range. Reduce or stop triamterene if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Sotalol with Triamterene?
MediHelp rates the interaction as moderate. Sotalol and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotalol is a nonselective beta-blocker that may modestly raise potassium, and triamterene retains potassium. Hyperkalemia can alter cardiac conduction, and sotalol's QT effects make electrolyte disturbances of particular concern.
How serious is the interaction between Sotalol and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG as appropriate, and keep potassium within the normal range. Reduce or stop triamterene if potassium rises.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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