Drug interactions
Sotalol + Vandetanib
Severity: Contraindicated
Sotalol and Vandetanib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and vandetanib carries a boxed warning for QT prolongation, torsades de pointes and sudden death. Combined use greatly increases the risk of life-threatening ventricular arrhythmia.
What this interaction means in plain words
Sotalol and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Sotalol belongs to Cardiovascular; Vandetanib belongs to Oncology.
Why it happens
Additive blockade of cardiac potassium channels (hERG) causing delayed repolarization and QT prolongation.
What to do
Avoid the combination; use a non-QT-prolonging antiarrhythmic or rate-control alternative. If it cannot be avoided, correct potassium and magnesium and perform frequent ECG monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Sotalol with Vandetanib?
MediHelp rates the interaction as contraindicated. Sotalol and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and vandetanib carries a boxed warning for QT prolongation, torsades de pointes and sudden death. Combined use greatly increases the risk of life-threatening ventricular arrhythmia.
How serious is the interaction between Sotalol and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-QT-prolonging antiarrhythmic or rate-control alternative. If it cannot be avoided, correct potassium and magnesium and perform frequent ECG monitoring.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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