Drug interactions
Sotorasib + Temsirolimus
Severity: Moderate
Sotorasib and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a weak P-gp inhibitor and a modest CYP3A4 inducer, so its effect on temsirolimus is not clearly established. Any change in exposure is expected to be small and the direction is uncertain.
What this interaction means in plain words
Sotorasib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sotorasib belongs to Oncology; Temsirolimus belongs to Oncology.
Why it happens
Possible P-gp and CYP3A4 modulation by sotorasib; the net effect on temsirolimus is not well established.
What to do
Monitor for temsirolimus toxicity and for reduced efficacy during combined use. No empirical dose change is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Sotorasib with Temsirolimus?
MediHelp rates the interaction as moderate. Sotorasib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a weak P-gp inhibitor and a modest CYP3A4 inducer, so its effect on temsirolimus is not clearly established. Any change in exposure is expected to be small and the direction is uncertain.
How serious is the interaction between Sotorasib and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for temsirolimus toxicity and for reduced efficacy during combined use. No empirical dose change is established.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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