Drug interactions
Sparsentan + Torsemide
Severity: Moderate
Sparsentan and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Torsemide is mainly cleared by CYP2C9, and sparsentan can induce this enzyme. Torsemide exposure may therefore fall, and its diuretic effect could be reduced. Sparsentan itself may also cause fluid retention or hypotension, complicating the picture.
What this interaction means in plain words
Sparsentan and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sparsentan belongs to Genitourinary; Torsemide belongs to Cardiovascular.
Why it happens
Sparsentan induction of CYP2C9 increases torsemide metabolism.
What to do
Monitor weight, edema and blood pressure after starting sparsentan and increase the torsemide dose if diuresis is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Sparsentan with Torsemide?
MediHelp rates the interaction as moderate. Sparsentan and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Torsemide is mainly cleared by CYP2C9, and sparsentan can induce this enzyme. Torsemide exposure may therefore fall, and its diuretic effect could be reduced. Sparsentan itself may also cause fluid retention or hypotension, complicating the picture.
How serious is the interaction between Sparsentan and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema and blood pressure after starting sparsentan and increase the torsemide dose if diuresis is inadequate.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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