Drug interactions
Sparsentan + Voriconazole
Severity: Major
Sparsentan and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is a CYP3A4 substrate, and voriconazole as a strong CYP3A4 inhibitor is expected to increase its exposure. This raises the risk of hepatotoxicity, hypotension, and fluid retention. The interaction is predicted from the mechanism rather than established by dedicated study.
What this interaction means in plain words
Sparsentan and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sparsentan belongs to Genitourinary; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, decreasing sparsentan metabolism and raising its plasma levels.
What to do
Avoid concurrent use if possible. If it cannot be avoided, interrupt sparsentan during azole therapy and monitor liver tests and blood pressure when it is restarted.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Sparsentan with Voriconazole?
MediHelp rates the interaction as major. Sparsentan and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sparsentan is a CYP3A4 substrate, and voriconazole as a strong CYP3A4 inhibitor is expected to increase its exposure. This raises the risk of hepatotoxicity, hypotension, and fluid retention. The interaction is predicted from the mechanism rather than established by dedicated study.
How serious is the interaction between Sparsentan and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible. If it cannot be avoided, interrupt sparsentan during azole therapy and monitor liver tests and blood pressure when it is restarted.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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