Drug interactions
Stiripentol + Sunitinib
Severity: Moderate
Stiripentol and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol both inhibits and induces CYP3A4, so sunitinib exposure may rise or fall unpredictably. This may cause toxicity or reduced efficacy.
What this interaction means in plain words
Stiripentol and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Sunitinib belongs to Oncology.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol altering sunitinib metabolism.
What to do
Monitor for sunitinib toxicity and for loss of response. Adjust the sunitinib dose according to tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Sunitinib?
MediHelp rates the interaction as moderate. Stiripentol and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol both inhibits and induces CYP3A4, so sunitinib exposure may rise or fall unpredictably. This may cause toxicity or reduced efficacy.
How serious is the interaction between Stiripentol and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sunitinib toxicity and for loss of response. Adjust the sunitinib dose according to tolerability.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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