Drug interactions
Stiripentol + Tadalafil
Severity: Moderate
Stiripentol and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both CYP3A4 inhibiting and inducing properties, so tadalafil exposure may rise or fall unpredictably. This could lead to adverse effects or loss of efficacy.
What this interaction means in plain words
Stiripentol and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Tadalafil belongs to Genitourinary.
Why it happens
Mixed inhibition and induction of CYP3A4 by stiripentol alters tadalafil metabolism.
What to do
Monitor response and tolerability of tadalafil after starting or stopping stiripentol, and adjust the tadalafil dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Tadalafil?
MediHelp rates the interaction as moderate. Stiripentol and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both CYP3A4 inhibiting and inducing properties, so tadalafil exposure may rise or fall unpredictably. This could lead to adverse effects or loss of efficacy.
How serious is the interaction between Stiripentol and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response and tolerability of tadalafil after starting or stopping stiripentol, and adjust the tadalafil dose accordingly.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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