Drug interactions
Stiripentol + Tolterodine
Severity: Minor
Stiripentol and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol both inhibits and induces CYP3A4 and also inhibits CYP2D6 in vitro, so the net effect on tolterodine exposure is unpredictable. Either increased anticholinergic effects or reduced efficacy may occur.
What this interaction means in plain words
Stiripentol and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Stiripentol belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Mixed CYP3A4 inhibition and induction, plus possible CYP2D6 inhibition, by stiripentol altering tolterodine metabolism.
What to do
Monitor both symptom control and anticholinergic adverse effects after starting or stopping stiripentol, and adjust the tolterodine dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Tolterodine?
MediHelp rates the interaction as minor. Stiripentol and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol both inhibits and induces CYP3A4 and also inhibits CYP2D6 in vitro, so the net effect on tolterodine exposure is unpredictable. Either increased anticholinergic effects or reduced efficacy may occur.
How serious is the interaction between Stiripentol and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor both symptom control and anticholinergic adverse effects after starting or stopping stiripentol, and adjust the tolterodine dose accordingly.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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