Drug interactions
Stiripentol + Tolvaptan
Severity: Moderate
Stiripentol and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP3A4 and P-glycoprotein but can also induce CYP3A4, so tolvaptan exposure could rise or fall. Higher exposure raises the risk of excessive aquaresis and rapid sodium correction, while lower exposure may reduce efficacy.
What this interaction means in plain words
Stiripentol and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Tolvaptan belongs to Endocrine.
Why it happens
Mixed CYP3A4 inhibition and induction plus P-glycoprotein inhibition by stiripentol alter tolvaptan clearance.
What to do
Monitor serum sodium and clinical response after starting or stopping stiripentol, and adjust the tolvaptan dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Tolvaptan?
MediHelp rates the interaction as moderate. Stiripentol and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP3A4 and P-glycoprotein but can also induce CYP3A4, so tolvaptan exposure could rise or fall. Higher exposure raises the risk of excessive aquaresis and rapid sodium correction, while lower exposure may reduce efficacy.
How serious is the interaction between Stiripentol and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and clinical response after starting or stopping stiripentol, and adjust the tolvaptan dose accordingly.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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