Drug interactions
Stiripentol + Tretinoin
Severity: Minor
Stiripentol and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes including CYP2C8, which contributes to tretinoin metabolism. Oral tretinoin exposure may increase, raising the likelihood of retinoid-related toxicity.
What this interaction means in plain words
Stiripentol and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Stiripentol belongs to Central Nervous System; Tretinoin belongs to Dermatology.
Why it happens
Inhibition of CYP2C8-mediated tretinoin metabolism by stiripentol.
What to do
Monitor for retinoid adverse effects when oral tretinoin is combined with stiripentol and reduce the tretinoin dose if toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Tretinoin?
MediHelp rates the interaction as minor. Stiripentol and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits several CYP enzymes including CYP2C8, which contributes to tretinoin metabolism. Oral tretinoin exposure may increase, raising the likelihood of retinoid-related toxicity.
How serious is the interaction between Stiripentol and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for retinoid adverse effects when oral tretinoin is combined with stiripentol and reduce the tretinoin dose if toxicity develops.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.
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