Drug interactions
Stiripentol + Vincristine
Severity: Moderate
Stiripentol and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP3A4 and P-glycoprotein and may also induce CYP3A4, so vincristine exposure may change unpredictably, mostly upward. Increased exposure could worsen neurotoxicity.
What this interaction means in plain words
Stiripentol and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Vincristine belongs to Oncology.
Why it happens
Stiripentol inhibits CYP3A4 and P-glycoprotein, with some CYP3A4 induction.
What to do
Monitor for neuropathy, constipation and reduced efficacy. Adjust the vincristine dose according to toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Vincristine?
MediHelp rates the interaction as moderate. Stiripentol and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP3A4 and P-glycoprotein and may also induce CYP3A4, so vincristine exposure may change unpredictably, mostly upward. Increased exposure could worsen neurotoxicity.
How serious is the interaction between Stiripentol and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, constipation and reduced efficacy. Adjust the vincristine dose according to toxicity.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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