Drug interactions
Succinylcholine + Verapamil
Severity: Minor
Succinylcholine and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil can potentiate neuromuscular blockade, and prolonged block has been reported with neuromuscular blockers. With succinylcholine the effect is usually modest but may lengthen recovery.
What this interaction means in plain words
Succinylcholine and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Succinylcholine belongs to Musculoskeletal; Verapamil belongs to Cardiovascular.
Why it happens
Reduced calcium influx at the presynaptic terminal and muscle may decrease acetylcholine release and enhance neuromuscular blockade.
What to do
Monitor neuromuscular function with a nerve stimulator and titrate relaxant dosing to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Succinylcholine
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Succinylcholine with Verapamil?
MediHelp rates the interaction as minor. Succinylcholine and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil can potentiate neuromuscular blockade, and prolonged block has been reported with neuromuscular blockers. With succinylcholine the effect is usually modest but may lengthen recovery.
How serious is the interaction between Succinylcholine and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator and titrate relaxant dosing to response.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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