Drug interactions
Succinylcholine + Voclosporin
Severity: Moderate
Succinylcholine and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can raise serum potassium, and succinylcholine releases potassium from muscle. Together they may cause additive hyperkalemia, especially in patients with reduced renal function.
What this interaction means in plain words
Succinylcholine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Succinylcholine belongs to Musculoskeletal; Voclosporin belongs to Miscellaneous.
Why it happens
Additive hyperkalemia from succinylcholine-induced potassium efflux and calcineurin inhibitor reduction of renal potassium excretion.
What to do
Check baseline potassium and renal function before anesthesia. Monitor potassium and ECG after succinylcholine, or choose a non-depolarizing agent if hyperkalemic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Succinylcholine
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Succinylcholine with Voclosporin?
MediHelp rates the interaction as moderate. Succinylcholine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin, a calcineurin inhibitor, can raise serum potassium, and succinylcholine releases potassium from muscle. Together they may cause additive hyperkalemia, especially in patients with reduced renal function.
How serious is the interaction between Succinylcholine and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline potassium and renal function before anesthesia. Monitor potassium and ECG after succinylcholine, or choose a non-depolarizing agent if hyperkalemic.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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