Drug interactions
Sufentanil + Voriconazole
Severity: Moderate
Sufentanil and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4, the main pathway for sufentanil, and can increase and prolong its opioid effects. This may lead to deeper sedation and respiratory depression.
What this interaction means in plain words
Sufentanil and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sufentanil belongs to Musculoskeletal; Voriconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition by voriconazole reduces sufentanil clearance.
What to do
Monitor sedation and respiratory function closely, particularly after repeated or prolonged dosing, and lower the sufentanil dose or infusion rate as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Sufentanil with Voriconazole?
MediHelp rates the interaction as moderate. Sufentanil and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4, the main pathway for sufentanil, and can increase and prolong its opioid effects. This may lead to deeper sedation and respiratory depression.
How serious is the interaction between Sufentanil and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory function closely, particularly after repeated or prolonged dosing, and lower the sufentanil dose or infusion rate as needed.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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