Drug interactions
Sulfamethoxazole + Ticlopidine
Severity: Minor
Sulfamethoxazole and Ticlopidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole is a CYP2C9 substrate, but ticlopidine is not a meaningful CYP2C9 inhibitor, so a clinically important increase is unlikely. Both drugs can cause hematologic adverse effects, so blood counts matter if used together.
What this interaction means in plain words
Sulfamethoxazole and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
The proposed CYP2C9 inhibition by ticlopidine is theoretical; additive hematologic toxicity is possible.
What to do
No dose adjustment is needed; monitor complete blood counts as per ticlopidine therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticlopidine
Frequently asked questions
Can I take Sulfamethoxazole with Ticlopidine?
MediHelp rates the interaction as minor. Sulfamethoxazole and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfamethoxazole is a CYP2C9 substrate, but ticlopidine is not a meaningful CYP2C9 inhibitor, so a clinically important increase is unlikely. Both drugs can cause hematologic adverse effects, so blood counts matter if used together.
How serious is the interaction between Sulfamethoxazole and Ticlopidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor complete blood counts as per ticlopidine therapy.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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