Drug interactions
Sulindac + Torsemide
Severity: Moderate
Sulindac and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and natriuretic response to loop diuretics and may cause fluid retention. The combination also increases the risk of acute kidney injury, especially in volume-depleted or elderly patients.
What this interaction means in plain words
Sulindac and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sulindac belongs to Musculoskeletal; Torsemide belongs to Cardiovascular.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, reducing renal blood flow and sodium excretion and counteracting loop diuretic effects.
What to do
Monitor blood pressure, weight, edema and renal function, and increase diuretic dose if response falls. Use the shortest NSAID course possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Torsemide
Frequently asked questions
Can I take Sulindac with Torsemide?
MediHelp rates the interaction as moderate. Sulindac and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the diuretic and natriuretic response to loop diuretics and may cause fluid retention. The combination also increases the risk of acute kidney injury, especially in volume-depleted or elderly patients.
How serious is the interaction between Sulindac and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight, edema and renal function, and increase diuretic dose if response falls. Use the shortest NSAID course possible.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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