Drug interactions
Sumatriptan intranasal + Vilazodone
Severity: Moderate
Sumatriptan intranasal and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans combined with serotonergic antidepressants have been associated with serotonin syndrome, although the absolute risk appears low. Patients should be informed of the symptoms.
What this interaction means in plain words
Sumatriptan intranasal and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from 5-HT1B/1D agonism and serotonin reuptake inhibition.
What to do
Use only if clinically needed and counsel on symptoms such as agitation, tremor, sweating, and fever. Stop both and treat supportively if serotonin syndrome occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Sumatriptan intranasal with Vilazodone?
MediHelp rates the interaction as moderate. Sumatriptan intranasal and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans combined with serotonergic antidepressants have been associated with serotonin syndrome, although the absolute risk appears low. Patients should be informed of the symptoms.
How serious is the interaction between Sumatriptan intranasal and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if clinically needed and counsel on symptoms such as agitation, tremor, sweating, and fever. Stop both and treat supportively if serotonin syndrome occurs.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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