Drug interactions
Sunitinib + Temsirolimus
Severity: Major
Sunitinib and Temsirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use has produced dose-limiting toxicities in clinical studies, including severe rash, gout, cellulitis, and other adverse effects. The combination is generally not tolerated at full doses.
What this interaction means in plain words
Sunitinib and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sunitinib belongs to Oncology; Temsirolimus belongs to Oncology.
Why it happens
The mechanism is not well established, and the combination appears to increase overlapping toxicities.
What to do
Avoid the combination. If treatment is needed, use sequential rather than concurrent therapy and monitor skin, joints and infection closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Sunitinib with Temsirolimus?
MediHelp rates the interaction as major. Sunitinib and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combined use has produced dose-limiting toxicities in clinical studies, including severe rash, gout, cellulitis, and other adverse effects. The combination is generally not tolerated at full doses.
How serious is the interaction between Sunitinib and Temsirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If treatment is needed, use sequential rather than concurrent therapy and monitor skin, joints and infection closely.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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