Drug interactions
Sunitinib + Tiotropium-olodaterol
Severity: Moderate
Sunitinib and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib can prolong the QT interval, and long-acting beta2 agonists such as olodaterol can add to cardiac effects including tachycardia, hypokalemia and arrhythmia. Combined use may modestly increase the risk of ventricular arrhythmias in susceptible patients.
What this interaction means in plain words
Sunitinib and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sunitinib belongs to Oncology; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and heart rate, with beta2-mediated hypokalemia.
What to do
Obtain a baseline ECG and monitor QTc and serum potassium and magnesium during combined use; correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Sunitinib with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Sunitinib and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib can prolong the QT interval, and long-acting beta2 agonists such as olodaterol can add to cardiac effects including tachycardia, hypokalemia and arrhythmia. Combined use may modestly increase the risk of ventricular arrhythmias in susceptible patients.
How serious is the interaction between Sunitinib and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and serum potassium and magnesium during combined use; correct electrolyte abnormalities.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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