Drug interactions
Sunitinib + Valbenazine
Severity: Moderate
Sunitinib and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QT interval, raising the risk of ventricular arrhythmia when combined. Valbenazine exposure rises in poor CYP2D6 metabolizers, adding to the risk.
What this interaction means in plain words
Sunitinib and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sunitinib belongs to Oncology; Valbenazine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization.
What to do
Obtain a baseline ECG and monitor ECG and electrolytes during coadministration. Correct hypokalemia and hypomagnesemia and reassess the combination if QTc lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Sunitinib with Valbenazine?
MediHelp rates the interaction as moderate. Sunitinib and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may prolong the QT interval, raising the risk of ventricular arrhythmia when combined. Valbenazine exposure rises in poor CYP2D6 metabolizers, adding to the risk.
How serious is the interaction between Sunitinib and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG and electrolytes during coadministration. Correct hypokalemia and hypomagnesemia and reassess the combination if QTc lengthens significantly.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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