Drug interactions
Suvorexant + Zileuton
Severity: Moderate
Suvorexant and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton may increase suvorexant levels by inhibiting CYP3A4. This can increase daytime somnolence and psychomotor impairment.
What this interaction means in plain words
Suvorexant and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Suvorexant belongs to Central Nervous System; Zileuton belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zileuton reduces suvorexant clearance.
What to do
Use the lowest suvorexant dose and avoid exceeding the maximum recommended with CYP3A4 inhibitors. Warn the patient about next-day drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Suvorexant and Zileuton, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Suvorexant
Frequently asked questions
Can I take Suvorexant with Zileuton?
MediHelp rates the interaction as moderate. Suvorexant and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zileuton may increase suvorexant levels by inhibiting CYP3A4. This can increase daytime somnolence and psychomotor impairment.
How serious is the interaction between Suvorexant and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest suvorexant dose and avoid exceeding the maximum recommended with CYP3A4 inhibitors. Warn the patient about next-day drowsiness.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
