Drug interactions
Tacrolimus + Teicoplanin
Severity: Moderate
Tacrolimus and Teicoplanin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidneys, and teicoplanin may add ototoxic potential. Together, they may increase the risk of acute kidney injury.
What this interaction means in plain words
Tacrolimus and Teicoplanin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Teicoplanin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity (tacrolimus afferent vasoconstriction with glycopeptide tubular injury).
What to do
Monitor serum creatinine and tacrolimus trough levels, and teicoplanin levels with prolonged therapy. Adjust doses for renal function and stop nephrotoxic drugs if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Teicoplanin
- Amphotericin b + Teicoplanin Major
- Cidofovir + Teicoplanin Major
- Neomycin + Teicoplanin Major
- Teicoplanin + Tobramycin Major
- Acyclovir + Teicoplanin Moderate
- Adefovir + Teicoplanin Moderate
Frequently asked questions
Can I take Tacrolimus with Teicoplanin?
MediHelp rates the interaction as moderate. Tacrolimus and Teicoplanin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidneys, and teicoplanin may add ototoxic potential. Together, they may increase the risk of acute kidney injury.
How serious is the interaction between Tacrolimus and Teicoplanin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tacrolimus trough levels, and teicoplanin levels with prolonged therapy. Adjust doses for renal function and stop nephrotoxic drugs if possible.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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