Drug interactions
Tacrolimus + Vardenafil
Severity: Moderate
Tacrolimus and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both vardenafil and tacrolimus can prolong the QT interval, so using them together may add to the risk of ventricular arrhythmia including torsades de pointes. The risk is greatest in patients with electrolyte disturbances, structural heart disease or other QT-prolonging drugs.
What this interaction means in plain words
Tacrolimus and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Vardenafil belongs to Genitourinary.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG in at-risk patients and correct potassium and magnesium before combining. Monitor the QTc and avoid adding other QT-prolonging agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Vardenafil?
MediHelp rates the interaction as moderate. Tacrolimus and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both vardenafil and tacrolimus can prolong the QT interval, so using them together may add to the risk of ventricular arrhythmia including torsades de pointes. The risk is greatest in patients with electrolyte disturbances, structural heart disease or other QT-prolonging drugs.
How serious is the interaction between Tacrolimus and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in at-risk patients and correct potassium and magnesium before combining. Monitor the QTc and avoid adding other QT-prolonging agents.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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