Drug interactions
Tacrolimus + Vinblastine
Severity: Moderate
Tacrolimus and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus is a P-glycoprotein and CYP3A4 substrate and inhibitor and may compete with vinblastine for clearance. This could raise vinblastine exposure and increase toxicity.
What this interaction means in plain words
Tacrolimus and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Vinblastine belongs to Oncology.
Why it happens
Tacrolimus competitively inhibits P-glycoprotein and CYP3A4 handling of vinblastine.
What to do
Monitor blood counts and for neurotoxicity, and reduce the vinblastine dose if toxicity appears. Check tacrolimus trough levels as clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Vinblastine?
MediHelp rates the interaction as moderate. Tacrolimus and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus is a P-glycoprotein and CYP3A4 substrate and inhibitor and may compete with vinblastine for clearance. This could raise vinblastine exposure and increase toxicity.
How serious is the interaction between Tacrolimus and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for neurotoxicity, and reduce the vinblastine dose if toxicity appears. Check tacrolimus trough levels as clinically indicated.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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